SynFlora: Pioneering the Future of Skin Care with Engineered Skin Microbes

At the recent 4YFN event in Barcelona, biotech startup SynFlora unveiled an intriguing concept for a revolutionary skin treatment technology. This Spanish startup, led by three PhD-holding co-founders, aims to revolutionize skincare by harnessing the power of the skin’s microbiome. Their mission is to engineer skin microbes that can deliver targeted therapeutics, unlocking a new era of personalized and effective treatments.

The key idea behind SynFlora’s approach is to go beyond the limitations of current topical skincare products. Instead of relying solely on molecules that often struggle to penetrate the skin’s surface, they envision a new generation of treatments powered by engineered bacteria. These bacteria can navigate deep into the skin’s layers, delivering therapeutic effects where they are needed most.

“We’re creating a foundation for a new kind of skin product that goes beyond mere molecules,” explains co-founder and CEO Nastassia Knödlseder. “It’s like a molecular machine, a bacteria that can penetrate the skin’s depths and produce novel effects.”

SynFlora’s initial research has focused on acne, and they’ve already published promising results in Nature Biotechnology. Their experimental treatment involves engineering skin microbes to produce a “sebum modulator,” effectively controlling oil production and reducing acne breakouts in mice.

However, the potential applications of SynFlora’s technology extend far beyond acne treatment. Knödlseder envisions a wide range of possibilities, including mosquito repellants, cellulite reduction creams, and even vaccines and anti-inflammatory treatments.

“We have the potential to trigger the immune system or create vaccines against skin conditions like melanoma,” she says. “We can also produce anti-inflammatory molecules to soothe irritated skin.”

SynFlora’s platform approach allows them to tailor their treatments to various skin concerns, opening up a world of possibilities for personalized skincare. They hold patents for different indications and the platform itself, ensuring they’re well-positioned to explore the full potential of their technology.

While SynFlora is still in its early stages, actively seeking seed funding, their vision is clear: to bring a new generation of skin-delivered therapeutics to market within the next one to three years.

With their innovative approach and unwavering dedication, SynFlora is poised to transform the skincare industry, offering targeted, effective, and personalized treatments that address a wide range of skin concerns.